The Toronto Pharmacol Building is architecturally significant as a good example of the early tall building type typified by the Classical organization and, in this case, Renaissance Revival detailing. Contextually, the building is an integral part of a series of early 20th century commercial buildings along the south side of King Street West, west of Spadina Avenue. The group contributes to the character of the King-Spadina neighbourhood as it developed as an industrial area in the early 1900s. The heritage attributes of the building are found on the exterior walls and roof with attention focused on the principal (north) façade. Rising three stories above a basement with window openings, the structure is faced with red brick and trimmed with stone. The north façade is organized into seven bays and features the Classical arrangement of base, shaft and cornice. The coursed rubblestone base is broken by the central entrance, which is recessed in an elaborate surround that mixes textured and smooth stonework under a semi-circular pediment with banding and brackets. An arcade of semi-circular arches supported on brick pilasters organizes flatheaded and round-arched window openings in the upper three stories. The vertical effect of the arcade is countered by horizontal lines formed by the sills (some with corbelled brickwork), incised lintels, and a projecting metal cornice with dentils. The cladding, pattern of openings and detailing wrap around the corners of the west elevation, which is finished with brown brick cladding and regularly-placed fenestration. The building abuts the neighbouring structure to the east.

The following companies are associated with this building

• Architect - John Francis Brown  <-- More buildings by this architect.