749-749B Queen Street West is a 2-to-2.5 storey building located on the south side of Queen Street West approximately 55 meters west of Tecumseth Street in the West Queen West neighbourhoood of Toronto. 749-749B Queen Street West was originally constructed as a residential property in either 1865/1866 or 1871/1872. The first commercial/retail uses of 749-749B Queen Street West emerged in the 1880s. Between circa 1903 and 1913, an addition was added on its Queen Street West (north) elevation. 749-749B Queen Street West also contains several rear additions dating to both the 19th and 20th century. The original structure — since altered with the early 20th century addition — may have been Georgian Revival in style.  

If constructed in 1865/1866, 749-749B Queen Street West was originally home to Jonathan Stubbs — an accountant and mercantile agent. Prior to 1865/1866, Stubbs lived a few buildings east on Queen Street West nearer to Tecumseth Street. 

If constructed in 1871/1872, 749-749B Queen Street West was purpose built as the parsonage for the neighbouring Euclid Avenue Primitive Methodist Church which was founded in 1864. During the 1870s (and regardless of its exact date of construction), 749-749B Queen Street West served as a parsonage.  The resident minister was Reverend Thomas Griffiths, who served at the pulpit of the Euclid Avenue Primitive Methodist Church between 1871 and 1876.  A new parsonage was constructed for the church in 1880. The Euclid Avenue Primitive Methodist Church later merged with the Queen Street Methodist Church (established 1838) in 1923. The congregation subsequently became known as the Queen Street United Church in 1925.

By 1879/1880, 749-749B Queen Street West was the home and practice of Toronto physician Dr. John Hodgkinson. 

By the late 1880s, 749-749B Queen Street West housed Burns & Sons — crockery merchants. By the turn of the 20th century, 749 Queen Street West housed A. Cunerty & Company — liquor merchants.  

Later uses of 749-749B Queen Street West include as a clothing shop during the early 1920s and as a paint and wallpaper store from the late 1920s through late 1970s. By the late 1970s, 749 Queen Street West also housed The Sinister Shoppe which specialized in goods for left-handed people. 

749-749B Queen Street West presently (as of January 2022) houses The Ten Spot — a nail and waxing salon.

(Research by Adam Wynne)