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Built in 1954, designed by Mathers and Haldenby, this is a more modest construction than its neighbour to the east, built 20 years earlier. It was named in honour of Dr. Charles H. Best, co-discoverer of insulin. The building is slated for demolition in 2019 to make way for the Schwartz-Reisman Centre for Innovation.
This substantial brick building was never identified as having heritage value in the discussions between the City and U of T during the 1990´s. Even though was designed by an important firm which might have been enough to warrant protection in another neighbourhood, as U of T needed to have space for potential expansion this building was given a lower rating when compared to other buildings on campus. It is to be replaced by the new Shwartz-Reisman Innovation Centre. Construction is expected to begin in the fall of 2019.