The Eliza Lennox Houses are considered culturally significant as a surviving group of row houses that are both architecturally distinct and representative of a major transformation of the King-Spadina neighborhood after the Great Fire of 1904.

Contextually, together with the John P. Jackson House (1880) at 445 Adelaide Street West (commissioned by Eliza Lennox’s brother), the houses are an important surviving collection of house form buildings of the King-Spadina neighbourhood, once a residential and institutional enclave before the Great Fire of 1904. After the Great Fire, the King-Spadina neighbourhood transformed into becoming the city's manufacturing hub. The Eliza Lennnox Houses 1904 construction date makes them a significant witness and representative of this major transitional time. 

The brick parapet that extends across all four units and incorporates a central segmental-arched pediment and terra cotta panels in the centre and on the ends is a defining feature of the row houses.

The Eliza Lennox Houses are historically, visually and physically related to their surroundings adjoining the southwest corner of Adelaide and Morrison streets, beside the John P. Jackson House (1880) at 445 Adelaide Street West and opposite St. Andrew’s Playground.