301 Queen Street East is a 2.5 storey building located on the south side of Queen Street East midblock between Ontario Street and Berkeley Street. 301 Queen Street East was built in 1874 in a Second Empire style of architecture. 

301 Queen Street East is an exceedingly rare example of a wooden Main Street Second Empire building located within Toronto. Almost all of the Second Empire buildings situated on Toronto's Main Streets are constructed of brick and/or stone.  

Prior to 1890, 301 Queen Street East was known as 245 Queen Street East.

301 Queen Street East was first home to Mrs. F. Miller's second hand clothing store in 1875. F. Miller was a widow. Limited information about F. Miller is available, albeit censuses yield two potential individuals: 

Mrs. F. Miller, born c. 1821 in Ireland.

Mrs. Flora Miller, born in 1852 in England. Flora Miller spoke German and was Jewish.


Later uses of the building include: Elizabeth Younger — confectioner (c. 1876/1877); William McBride — general jobber (c. 1877/1878); Edward and Sarah Boddy — painters (with a Post Office based in their shop) (c. 1880s-1900s); Leo Dinovo — fruit store (c. 1910); Solomon Sehr — second hand goods (c. 1910s-1930s); Nick Mikalacki —poultry (c. 1950); Gloria's Restaurant (c. 1960s); and Josef's Fashion for Men (c. 1980s).


301 Queen Street East is presently vacant and has been proposed for demolition as part of the redevelopment of 301-317 Queen Street East.